解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科，口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学，全科和内科
医学，法律
医学，研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学，核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学，临床
abstract：OBJECTIVE:The current study examined serum CK activity following bench press (BP) and leg press (LP) exercise-induced muscle damage to evaluate agreement of subjects classification as either high (HiR) or normal responders (NoR) between upper and lower body muscle groups. METHODS:Forty-two men performed two resistance...
journal_title：Journal of musculoskeletal & neuronal interactions
pub_type： 杂志文章,随机对照试验
doi：
更新日期：2013-03-01 00:00:00
abstract：UNLABELLED:Osteogenesis imperfecta (OI) is a genetically heterogeneous disease leading to bone fragility. OI-VI is an autosomal-recessive form caused by mutations in SERPINF1. There is experimental evidence suggesting that loss of functional SERPINF1 leads to an activation of osteoclasts via the RANK/RANKL pathway. Pat...
journal_title：Journal of musculoskeletal & neuronal interactions
pub_type： 杂志文章
doi：
更新日期：2012-09-01 00:00:00
abstract：:A randomized controlled trial was conducted to compare the effect of a one-leg standing exercise and a chair-rising exercise on body balance in patients with locomotive disorders. Thirty ambulatory patients (mean age: 66.6 years) were randomly divided into two groups (n=15 in each group): a one-leg standing exercise g...
journal_title：Journal of musculoskeletal & neuronal interactions
pub_type： 杂志文章,随机对照试验
doi：
更新日期：2012-06-01 00:00:00
abstract：OBJECTIVES:The relationship between thoracic spine dysfunction and painful shoulder pathologies is poorly understood. This study sought to determine the intra-rater reliability of a protocol aimed at assessing the active mobility of the thoracic spine in individuals with chronic rotator cuff pathology. METHODS:Ten ind...
journal_title：Journal of musculoskeletal & neuronal interactions
pub_type： 杂志文章
doi：
更新日期：2011-12-01 00:00:00
abstract：OBJECTIVE:To compare the accuracies of two simple physical examination maneuvers for detecting the presence of thoracic vertebral fractures (VF) diagnosed by radiography: direct measurement of kyphosis angle (KA, in degrees) and indirect measurement using wall-occiput distance (WOD, in cm). METHODS:Subjects were 280 w...
journal_title：Journal of musculoskeletal & neuronal interactions
pub_type： 临床试验,杂志文章
doi：
更新日期：2011-09-01 00:00:00
abstract：OBJECTIVES:To quantify the intratendinous levels of substance P (SP) at different stages of overload in an established model for Achilles tendinopathy (rabbit). Also, to study the distribution of the SP-receptor, the NK-1R, and the source of SP, in the tendon. METHODS:Animals were subjected to the overuse protocol for...
journal_title：Journal of musculoskeletal & neuronal interactions
pub_type： 杂志文章
doi：
更新日期：2011-06-01 00:00:00
abstract：:Bone strains are the most important factors for osteogenic adaptive responses. During the past decades, scientists have been trying to describe the relationship between bone strain and bone osteogenic responses quantitatively. However, only a few studies have examined bone strains under physiological condition in huma...
journal_title：Journal of musculoskeletal & neuronal interactions
pub_type： 杂志文章,评审
doi：
更新日期：2011-03-01 00:00:00
abstract：OBJECTIVES:We sought to identify the variance in radius bone strength indices explained by forearm muscle cross sectional area (MCSA) and isometric (ISO), concentric (CON), or eccentric (ECC) grip torque in healthy men and postmenopausal women when gender and body size were controlled for. Additionally we assessed vari...
journal_title：Journal of musculoskeletal & neuronal interactions
pub_type： 杂志文章
doi：
更新日期：2010-06-01 00:00:00
abstract：:Myostatin (GDF-8) is a member of the transforming growth factor-beta (TGF-beta) superfamily that is highly expressed in skeletal muscle, and myostatin loss-of-function leads to doubling of skeletal muscle mass. Myostatin-deficient mice have been used as a model for studying muscle-bone interactions, and here we review...
journal_title：Journal of musculoskeletal & neuronal interactions
pub_type： 杂志文章,评审
doi：
更新日期：2010-03-01 00:00:00
abstract：OBJECTIVES:The current study aimed to examine the effectiveness of a resistive vibration exercise countermeasure during prolonged bed-rest in preventing lower-limb muscle atrophy. METHODS:20 male subjects underwent 56-days of bed-rest and were assigned to either an inactive control, or a countermeasure group which per...
journal_title：Journal of musculoskeletal & neuronal interactions
pub_type： 杂志文章
doi：
更新日期：2009-10-01 00:00:00
abstract：OBJECTIVE:To evaluate if exercise in a young growing model of obesity would be able to reduce adiposity without adversely affecting bone. METHODS:Obese (fa/fa) and lean (Fa/Fa) male Zucker rats were randomly assigned (n=8-9 rats/group) to no exercise or to a moderate treadmill exercise regimen consisting of a speed of...
journal_title：Journal of musculoskeletal & neuronal interactions
pub_type： 杂志文章
doi：
更新日期：2009-07-01 00:00:00
abstract：:In both sexes, a reduction in sex steroid production with aging impairs the musculoskeletal system. The goal of our study was to test the ability of WH-9062, a novel non-steroidal small molecule inhibitor of the 17beta-Hydroxysteroid Dehydrogenase type 2 enzyme, to maintain or improve bone strength without raising ser...
journal_title：Journal of musculoskeletal & neuronal interactions
pub_type： 杂志文章
doi：
更新日期：2008-07-01 00:00:00
abstract：:While bone adaptive response to its mechanical environment was considered to be controlled locally by cytokines and systemic hormones, some recent work suggests that it could also be neuronally regulated. Bone is indeed very densely innervated and many experimental and clinical studies have previously shown the involv...
journal_title：Journal of musculoskeletal & neuronal interactions
pub_type： 杂志文章,评审
doi：
更新日期：2008-04-01 00:00:00
abstract：:Strontium ranelate (SR) is a novel anti-osteoporotic agent approved for the treatment of postmenopausal osteoporosis. SR appears to reduce bone resorption by decreasing osteoclast differentiation and activity, and to stimulate bone formation by increasing replication of pre-osteoblast cells, leading to increased matri...
journal_title：Journal of musculoskeletal & neuronal interactions
pub_type： 杂志文章,评审
doi：
更新日期：2007-07-01 00:00:00
abstract：INTRODUCTION:Growth factors, cytokines, sex steroid hormones and glucocorticoids have differential and complex effects on skeletal metabolism. Recently, the presence of the glutamatergic (Glu) system in bone cells has provided new evidence for its possible role in bone physiology. Consequently, we have investigated the...
journal_title：Journal of musculoskeletal & neuronal interactions
pub_type： 杂志文章
doi：
更新日期：2007-04-01 00:00:00
abstract：:Bisphosphonates (formerly termed diphosphonates) were first synthesized in the late 1800s; however, their clinical use has been relatively recent. The bisphosphonates' affinity for hydroxyapatite crystal surface led Procter and Gamble to test these compounds in dental, then medical applications. With key input from un...
journal_title：Journal of musculoskeletal & neuronal interactions
pub_type： 历史文章,杂志文章,评审
doi：
更新日期：2007-01-01 00:00:00
abstract：:Current published results on whether statins have beneficial effects on bone metabolism have been conflicting so far. In order to further investigate if statins were promising candidates for the treatment for osteoporosis, we conducted a study in which rats were ovariectomized (OVX) at 6 months of age, allowed to lose...
journal_title：Journal of musculoskeletal & neuronal interactions
pub_type： 杂志文章
doi：
更新日期：2006-07-01 00:00:00
abstract：:The concept of the mechanostat was not new in 1983, when Harold Frost coined the term to describe a mechanism by which bone responded to habitual exercise and changes in loading with structurally appropriate alterations in bone architecture. However, the word "mechanostat" has a meaning that is immediately apparent, a...
journal_title：Journal of musculoskeletal & neuronal interactions
pub_type： 杂志文章,评审
doi：
更新日期：2006-04-01 00:00:00
abstract：:Tendon disorders are frequent, and are responsible for much morbidity both in sport and the workplace. Although the presence of degenerative changes does not always lead to symptoms, pre-existing degeneration has been implicated as a risk factor for acute tendon rupture. The term tendinopathy is a generic descriptor o...
journal_title：Journal of musculoskeletal & neuronal interactions
pub_type： 杂志文章,评审
doi：
更新日期：2006-04-01 00:00:00
abstract：:The genetics of osteoporosis can be considered in two broad areas: disease susceptibility and drug activity. While the former has been studied, the latter is still largely untouched. Pharmacogenomics is the utilization of genetic information to predict outcome of drug treatment, with respect to both beneficial and adv...
journal_title：Journal of musculoskeletal & neuronal interactions
pub_type： 杂志文章,评审
doi：
更新日期：2006-01-01 00:00:00
abstract：:Bone growth in length is primarily achieved through the action of chondrocytes in the proliferative and hypertrophic zones of the growth plate. Longitudinal growth is controlled by systemic, local paracrine and local mechanical factors. With regard to the latter, a feedback mechanism must exist which ensures that bone...
journal_title：Journal of musculoskeletal & neuronal interactions
pub_type： 杂志文章,评审
doi：
更新日期：2005-07-01 00:00:00
abstract：:Skeletal anomalies are observed in neurofibromatosis type 1 (NF1), but the pathogenesis is unknown. Given that muscle mass is important in the development of the strength of bone, peripheral quantitative computed tomography (pQCT) was utilized to compare measurements of muscle compartments between NF1 individuals and ...
journal_title：Journal of musculoskeletal & neuronal interactions
pub_type： 杂志文章
doi：
更新日期：2005-06-01 00:00:00
abstract：:Connective tissue of the human tendon plays an important role in force transmission. The extracellular matrix turnover of tendon is influenced by physical activity. Blood flow, oxygen demand, and the level of collagen synthesis and matrix metalloproteinases increase with mechanical loading. Gene transcription and espe...
journal_title：Journal of musculoskeletal & neuronal interactions
pub_type： 杂志文章,评审
doi：
更新日期：2005-03-01 00:00:00
abstract：:It has previously been established that zinc (Zn) supplementation increases bone dimensions and strength in growing rats. The present study aims at describing differences in the localization of loosely bound or free zinc ions, as revealed by autometallography (AMG), that might take place in the skeleton of growing rat...
journal_title：Journal of musculoskeletal & neuronal interactions
pub_type： 杂志文章
doi：
更新日期：2004-12-01 00:00:00
abstract：:Thyroid hormones affect bone remodelling directly via receptors in osteoblasts. Previously, however, we have shown that the euthyroid and hyperthyroid states significantly influence the concentrations of both nerve growth factor (NGF) and norepinephrine (NE) in particular bones. Both NGF and NE directly affect bone me...
journal_title：Journal of musculoskeletal & neuronal interactions
pub_type： 杂志文章
doi：
更新日期：2004-09-01 00:00:00
abstract：:The amino acid L-glutamate mediates signals at excitatory synapses in the CNS where its effects are controlled by co-ordinated activities of various types of glutamate receptor and transporter. This signalling mechanism has proved to be far more ubiquitous with many different cell types responding to glutamate. The gl...
journal_title：Journal of musculoskeletal & neuronal interactions
pub_type： 杂志文章,评审
doi：
更新日期：2004-06-01 00:00:00
abstract：:Age-related sarcopenia leads to muscle weakness and a concomitant increase in gait problems and the risk of hip fracture due to falling in the elderly. Muscle weakness reduces general activity levels in elderly individuals which in turn elevates the risk of osteoporosis due to a decrease in overall mechanical loading ...
journal_title：Journal of musculoskeletal & neuronal interactions
pub_type： 杂志文章,评审
doi：
更新日期：2004-06-01 00:00:00
abstract：:Here a voice from the past suggests 28 changes that will affect how people study, manage, classify and think about "osteoporoses" today. Those changes depend mainly on two things: (i) "Connecting the dots" between diverse evidence and ideas from many fields and sources in order to find larger "messages" hidden in moun...
journal_title：Journal of musculoskeletal & neuronal interactions
pub_type： 杂志文章,评审
doi：
更新日期：2004-03-01 00:00:00
abstract：:All epidemiological studies conclude that without prompt, concerted and well-designed prevention programs, the increasing cost related to osteoporotic fractures will become an unbearable burden for the community within the next fifteen years. However, the most effective way of setting up such preventive strategies is ...
journal_title：Journal of musculoskeletal & neuronal interactions
pub_type： 杂志文章
doi：
更新日期：2003-09-01 00:00:00
abstract：:The pathogenesis of osteogenesis imperfecta (OI) baffled physiologists and physicians for over a century. Most past efforts to explain it depended heavily on cell and molecular biology and on changes in the material properties of affected bones (an old idea that OI patients could not make enough bone erred). To such v...
journal_title：Journal of musculoskeletal & neuronal interactions
pub_type： 杂志文章
doi：
更新日期：2003-03-01 00:00:00
abstract：:An important consideration in interpreting indices of gene expression in human bone is relating mRNA levels to functional endpoints such as bone architecture. In the present study, a method was developed for quantitative measurement of gene expression and bone morphology in the same specimen. Three-dimensional images ...
journal_title：Journal of musculoskeletal & neuronal interactions
pub_type： 杂志文章
doi：
更新日期：2003-03-01 00:00:00
abstract：:There has been increasing evidence during the last years that glutamate (Glu), the major neuromediator of the nervous system, contributes to the local regulation of bone cell functions. Several classes of Glu receptors and transporters, as well as molecules involved in glutamate signal transduction in neuronal tissue,...
journal_title：Journal of musculoskeletal & neuronal interactions
pub_type： 杂志文章
doi：
更新日期：2002-09-01 00:00:00
abstract：:Projectional bone mineral density measurement so far used extensively in radiogrammetry and single and dual source absorptiometry is confronted with a serious limitation for the accurate evaluation of true density artifactually providing higher values along with the increase of body size and bone depth on account of t...
journal_title：Journal of musculoskeletal & neuronal interactions
pub_type： 杂志文章
doi：
更新日期：2002-06-01 00:00:00
abstract：:The rationale for use of inbred strains of mice in bone research is well recognized and includes: a) practical factors (economics of scale, rapid development of adult status, pre-existing knowledge, down-sized technologies) and b) proven methodologies for genetic studies (polygenic trait analyses, mapping tools, genom...
journal_title：Journal of musculoskeletal & neuronal interactions
pub_type： 杂志文章
doi：
更新日期：2002-03-01 00:00:00
abstract：:The field of developmental biology has a history that spans the last 500 years. Within the last 10 years, our understanding of developmental mechanisms has grown exponentially by employing modern techniques of genetics and molecular biology, frequently combined with experimental embryology and the use of molecular mar...
journal_title：Journal of musculoskeletal & neuronal interactions
pub_type： 杂志文章
doi：
更新日期：2002-03-01 00:00:00
abstract：:Growing evidence supports a 1972 proposal that dynamic tension strains of a ligament above a threshold range, but below its ultimate strength, would make its cells synthesize more collagen to thicken and strengthen it. If so, when that strengthening reduced later strains to the bottom of that threshold range this "dia...
journal_title：Journal of musculoskeletal & neuronal interactions
pub_type： 杂志文章
doi：
更新日期：2001-12-01 00:00:00
abstract：:Animal models are suitable to study many aspects of bone structure and strength. This article reviews some general principles of current bone biomechanics and describes the scope of the available methodology for biomechanical studies of the musculoskeletal system employing those models. The analysis comprises bone and...
journal_title：Journal of musculoskeletal & neuronal interactions
pub_type： 杂志文章
doi：
更新日期：2001-03-01 00:00:00
abstract：AIM OF THE STUDY:To determine whether and when, like after estrogen withdrawal, bone loss resumes once disodium pamidronate is discontinued, even after long duration therapy. MATERIALS AND METHODS:19 patients with osteoporosis, previously treated for 4.3 -/+ 0.5 years (SEM) with oral cyclical intermittent pamidronate,...
journal_title：Journal of musculoskeletal & neuronal interactions
pub_type： 杂志文章
doi：
更新日期：2000-12-01 00:00:00
abstract：:There is great interest in the relationships between growth hormone (GH), muscle loading and bone, in part, because GH increases muscle mass which provides the largest signals that control bone modeling and remodeling. This study was designed to examine the effects of GH and muscle loading by exercise (EX) independent...
journal_title：Journal of musculoskeletal & neuronal interactions
pub_type： 杂志文章
doi：
更新日期：2000-09-01 00:00:00
